Philip Anthony McMillan
Hull and East Yorkshire Hospitals NHS Trust, UK
Title: Integrated biochemical theory of delirium and experience with Pharmacological reversal
Biography
Biography: Philip Anthony McMillan
Abstract
Delirium is a significant problem in older hospital admissions, with worse clinical outcomes, prolonged hospital stay and functional disability. This presentation will cover the clinical experience of managing these complex patients during their hospital stay. The basis of this theory is with hepatic encephalopathy and the fact that all forms of delirium are clinically consistent. Looking to explain the integrated theory of delirium based on brain glutamate and ammonia management. This will demonstrate the biochemical aspects of delirium and how it is related to other conditions and most significantly how there is a higher incidence of delirium in dementia. Anecdotal experience of reversing delirium using this biochemical framework and use of simple medication in hospital has been very successful with up to 70% of patients demonstrating clinical improvement. This theory has the potential to revolutionize our care of older patients and give insight into the links between delirium and dementia.